Alvarez, Julia historical novel on child abuse - Saving the World  - AIDS novel is based on true small-pox incidents.  Main plot =  Isabel, accompanied a doctor from Spain to the New World in 1803 to help rid the world of smallpox, resulting in young orphaned boys being used as the carriers for the smallpox vaccination.
Part of the novel is based on a real, historical event. In 1803 a lone woman, accompanied by a small band of medical men and 22 orphaned boys from Spain, embarked on a journey across the Atlantic Ocean to save the world. Under the leader-ship of Dr. Francisco Xavier Balmis, the royally sanctioned mission aimed to vaccinate as many people as possible in the New World and eradicate the dreaded smallpox disease.
This was before refrigeration, so Balmis "had calculated that exactly 22 carriers would be needed" for the initial round of vaccinations after the group had reached Western shores. The orphans were living smallpox vaccine "carriers," and the carriers had to be vaccinated sequentially, 2 at a time, so the vaccine would not be lost if it did not take in 1 of the selected pair of boys.

Day, Dr Lorraine - hypothesis -  Small Pox


Preston, Richard The Demon in the Freezer

Small Pox - radio interview with author Michael Willrich -
2011/04/05/135121451/how-the-pox-epidemic-changed-vaccination-rules  recommended read/listen -
Mike leans towards the benefits of vaccinations, while sympathizing with pathos of parents. 4/5/2011

Speckled Monster -

Variola, vaccinia—what is smallpox?



Roos, Grace Ryerson - booklet - Chapter 14 How To -
A lady resisted smallpox for herself & family. 1 of them broke out with it, but she seated herself by the bed & told God she would not cease to resist until the disease went. Every bit of the disease disappeared, & no one else took it. She resisted steadfastly...& found Him faithful who had promised."

Medical Research

Medical Alert

3. Smallpox vaccine causes cardiac arrest - 11/2/2020 -
- The DOD implemented a smallpox vaccine pilot study in 2002 for 450,000 military members as a bioterror counter-measure for a viral smallpox exposure. Dr. William Winkenwerder, (USA) DOD’s assistant secretary of defense for Health Affairs, concluded that the vaccine was safe, even though about 1 in 12,000 people who received the vaccine experienced a rare side effect: acute myopericarditis or inflammation of the membrane covering the heart. However, Army Col. John D. Grabenstein, the Military Vaccine Agency’s deputy director for clinical operations, refuted media reports of the vaccine causing heart attacks in military members. In the American Forces Press Service, Grabenstein said, “We have had several heart attacks among (those receiving) smallpox vaccines, but no more than we have had among a similar amount of unvaccinated people, so our conclusion is that heart attacks & smallpox vaccination are unrelated.” These 2 co-authors said the vaccine’s common side effects were limited to blisters, itching & a day of feeling sick. 
The FDA’s “
Highlights of Prescribing Information” for the smallpox vaccine clearly details cardiac events as a serious adverse reaction in both the DOD program & the clinical trials at an estimated incidence rate of 6.9 per 1000. The DOD smallpox program reported 86 cases of myocarditis or pericarditis out of 730,580 people who received the Dryvax brand smallpox between 2002-2005. The clinical trials of ACAM2000 brand and Dryvax brand reported 10 cases of myocarditis in 3851 subjects. The FDA reports that not only can the smallpox vaccine cause death resulting from sudden cardiac arrest, but also that “death has also been reported in unvaccinated contacts accidentally infected by individuals who have been vaccinated.” Furthermore, severe vaccine-related adverse events, defined as interfering with normal activities, were reported in 10%-13% of subjects. 
According to the 
2003 GAO Report “Smallpox Vaccination: Review of the Implementation of the Military Program,” DOD implemented the 2002 smallpox vaccine with unprecedented cautions: a phased roll-out, a screening form for contraindications, allowed exemptions, a newly utilized active monitoring system for vaccine adverse reactions called the Defense Medical Surveillance System (DMSS) & training for medical providers on safe vaccine storage & treatment protocols for adverse reactions. The GAO report detailed 184 noteworthy adverse reactions among 501,946 vaccinations in the 1st year of the smallpox vaccine program. None of these safety measures & surveillance systems were in place for the highly-reactive anthrax vaccine program roll-out in 2001, the year prior for the entire military.