Bromelain Supplements come from the core of the pineapple. "Bromelain is a general name for a family of sulfhydryl proteolytic enzymes obtained from Ananas comosus, the pineapple plant. It is usually distinguished as either fruit bromelain or stem bromelain depending on its source, with all commercially available bromelain being derived from the stem.1 The term bromelain will be used to refer to stem bromelain in the remainder of this article."  It is mostly used as an an antinflammatory.