Hist-amine (low = hista-penia) (high = hista-delia)

histapenia (low histamine/over methylated) or histadelia (high histamine/under methylated)
Hist-amine is an amine produced by decomposition of histidine and found in all organic matter.   It is a powerful constrictor of blood vessels and a stimulator of gastric secretions.  Webster's dictionary

Pfeiffer, Dr. Carl - https://www.secondopinionphysician.com/shop/walsh-protocol-lab-test-histamine-methylation/ good
"In the 1950’s the late Carl Pfeiffer, MD recongnized the role of histamine in schizophrenia...
From the BIoBalance website it is noted that he found that histapenia, or low histamine was present in as many as 50%
of persons with ‘schizophrenia’ (symptoms/label).  HistapeniaHistamine is an important brain chemical involved in many reactions. It has been found that 50% of patients classified as “schizophrenic” have low histamine levels in the blood and it rises to normal as they improve. These same patients are found to have (too) high copper levels. Elevated copper decreases blood histamine. Excess copper is linked with psychosis. According to Pfeiffer, people with histapenia tend to have classic signs, including canker sores, difficult orgasm with sex, no headaches or allergies, heavy growth of body hair, ideas of grandeur, undue suspicion of people, racing thoughts, the feeling that someone controls one’s mind, seeing or hearing things abnormally, ringing in the ears, and others.
Histadelia – his is a disorder of too much histamine in the blood, noted primarily in males with schizophrenia."



Histidine/histidin is an amino acid formed by the hydrolysis of proteins.


Subtypes of schizophrenia may include histapenia, histadelia, high copper levels or cerebral allergies and pyroluria, often remediated with B6 (taken AM) & zinc + other supplements.  www.diagnose-me.com


Enzyme found in the animal digestive system, capable of inactivating histamine.


Methylation - http://www.autismcoach.com/Methylation%20-%20Over%20or%20Under.htm -  
Supplements that tend to benefit OVER-methylators: 
non-methylated (forms of) B vitamins [folic acid-B9 (folate), B-12, niacin (B3 or niacinamide), B-6], and DMAE...
OVER-methylators tend to become hyper and 'stimmy' given methyl donors. 
Generally they should AVOID methionine SAMe, TMG, DMG, and methylated B vitamins."
Major Mental Illness Biochemical Subtypes - www.nutritional-healing.com.a...mical+Subtypes - methylation imbalance - excellent - http://www.nutritional-healing.com.au/content/articles-content.php?heading=Major+Mental+Illness+Biochemical+Subtypes -
Pfeifer - http://www.nutritional-healing.com.au/content/articles-content.php?heading=Major%20Mental%20Illness%20Biochemical%20Subtypes
Pfeifer on Methylation - oxidative stress - Alternative Mental Health - http://www.alternativementalhealth.com/articles/walshMP.htm
Alternative Medicine
Hammel, John - http://www.iahf.com/on_the_back_wards.html - "Pfeiffer www.orthomed.org discovered that food and inhalant allergies caused me to have an overproduction of histamine which is peripherally stored in basophils of the blood and the tissue mast cells. Basophil counts greater than 50 cells/cu mm and histamine levels greater than 70 ng/ml (10 mcg%) are considered diagnostic for histadelia. The average histamine for males was 111 mg/ml and females 107 mg/ml in a study reported in 1975. My histamine levels were up to 126. This is significantly different from normals: 42 and 46 mg/ml for males and females respectively. Histadelia causes suicidal depression, paranoia, and obsessive thinking.
The amino acid methionine detoxifies histamine by methylating the ring structure forming N-methylhistamine. Calcium, taken in the form of calcium salts reduces the release of the bodies store of histamine. Zinc and manganese aid the calcium-methionine program and provide sufficient relief.
Pfeiffer also discovered that I had very high aluminum levels, and copper levels, as well as overproduction of an enzyme called kryptopyrolle. This enzyme robbed me of zinc, a copper antagonist that I needed to eliminate excess copper which was having an excitory effect on the brain as an electrolyte, contributing to my difficulty concentrating, to thought disorder as well as to my severe depression. In essence: high copper levels were shorting out my brain, interfering with neural firing. Zinc, Manganese, and vitamin C all help to lower a copper burden. The amino acids l-tyrosine, and l-tryptophan boost norepeniphrine and dopamine levels respectively, also helping to alleviate depression."

Hoffer, Abram - https://www.boragebooks.com/schizophrenia_treatments.html - 2009 by Eva Edelman -
- Histapenia is characterized by depressed (insufficient) blood levels of histamine, brain (excess) over-methylation with low folate, and, usually, excess copper. Histapenia, combined with metal metabolism dysfunction, is the most prevalent biotype in schizophrenia, affecting an estimated 40-50% of patients. It may be present in 90 to 95% of paranoid schizophrenics...
Patients with histapenia tend to have classic schizophrenic symptoms (paranoia, grandiosity, hallucinations, thought disorder). They are also often highly creative as artists or musicians...
Treatment now typically includes not only B3 and C, but also folic acid (B9), B6, B12, zinc, manganese, vitamin E, selenium, other antioxidants, omega 3 and various other nutrients, as per individual need. Also, restriction of copper...
- Nijinski, the much-acclaimed Russian dancer, was diagnosed incurably insane. Nijinsky may have been histadelic. One of the 1st indications of illness occurred when Nijinsky, who had been a devoted and kindly father and husband, pushed his wife and infant child downstairs. Later, when asked about this, he seemed confused. He often refused food, particularly meat, for long stretches of time. He became increasingly obsessed with visions of dead soldiers. He never recovered and never danced again, although his wife found that he always remembered every move of every dance he ever performed...
Histadelia is characterized by elevated (excess) blood histamine, and brain (insufficient) under-methylation with excessive folic acid accumulation. An estimated 15-20% of schizophrenics are histadelic. Histadelics tend to work compulsively, and often excel in the sciences or sports, but are prone to a relatively constant and severe depression, as well as obsessions, compulsions, and addictions...
Typical treatment may include magnesium, calcium, B6, C, methyl-B12, glutathione, omega 3, methionine and/or SAMe, and various other nutrients, according to individual requirements. Folic acid is almost always elevated and must be restricted...
- Poet, Emily Dickinson, though not schizophrenic, displayed many pyroluric characteristics. Although reasonably happy as a child, as a teenager, she became increasingly isolated. Eventually, new people and situations became so stressful that she chose to have personal contact only with her family, communicating with close friends only by letter. Throughout her life, she was plagued by intermittent depression, cluster headaches, fatigue, and severe eye pain...
Pyroluria is a stress and oxidative stress disorder, characterized by elevation in certain urinary pyrroles. It is the primary imbalance for approximately 20% of schizophrenics. Pyrolurics can also have histamine imbalances...
Pyrolurics are generally anemic, pale, and prone to nausea, joint pain, irritability and anxiety. Depression can lead to suicide. Mental symptoms become particularly severe when under stress...
Pyrolurics commonly respond within several weeks to months to B6, zinc, manganese, GLA, antioxidants, and other nutrients. Limiting exposure to stressors and toxins is important. The nutrient dosage is significantly increased when anticipating or undergoing stress...
Cerebral allergy
- In 1949 Mary Hollister was referred to Dr. Theron Randolph for incapacitating headaches, extreme hyperactivity and severe depression. In his office she ate some beets she had brought with her, and two hours later was hospitalized for psychosis. Later, she became depressed and disoriented, and then, all symptoms ended. When Randolph tested her with beets, she again became temporarily psychotic. This case marked the beginning of investigations into the connection between allergy and schizophrenia...
Dr. William Philpott has found that, on average, 92% of schizophrenics show mental reactions to allergens, with an average of 10 substances eliciting reactions per patient. Common allergens include dairy, glutenous grains, tobacco, caffeine, sugar, nightshades (potato family), etc...
Treatment typically involves nutritive support, avoiding the allergen, desensitization, and attention to contributory conditions (e.g., Candida, mercury overload, sugar imbalances, thyroid disorder, adrenal exhaustion)...
Miscellaneous nutritional imbalances
- in perhaps 10% of cases, assorted nutritional deficiencies or excesses, not encompassed above, are the major consideration. Malabsorption is often a factor.

Walsh, William - Pfeiffer Treatment -
Biochemical Treatment: Medicines for the Next Century discussion of low and high histamine and treatment