|Elizabeth Blackburn, Jack Szostak & Carol Greider @ The 2009 Nobel Prize in Physiology or Medicine - Press release - NobelPrize.org - DNA/chromosome ends are protected by telomeres that are built by enzyme telomerase: Enzyme telomerase...consists of RNA as well as protein. The RNA component...contains the CCCCAA sequence. It serves as the template when the telomere is built, while the protein component is required for the construction work, i.e. the enzymatic activity. Telomerase extends telomere DNA, providing a platform that enables DNA polymerases to copy the entire length of the chromosome without missing the very end portion (thus) Telomeres delay aging of the cells."|
Ahmed, Aftab J The Health Benefits of Human
Keats Good Health Guide booklet - www.keats.com
If the senior citizen is exercising & consuming an adequate/balanced/nutritional diet daily, then adding supplements may improve one's metabolism. Glutamine with niacinamide supplementation before exercise & especially at bedtime may increase the stimulation of one's own growth hormone.
One can substitute the amino acids ornithine or arginine with lysine; but this requires higher dosages.
Ames, Bruce "University of Bari in Italy
had reported that feeding acetyl-L-carnitine
to old rats improves the function of their mitochondria...Ames...could
see how the supplement might achieve its effects:
Acetyl-L-carnitine, also known as Alcar, is a nutrient that helps transport fatty-acid fuel across lipid membranes into mitochondria...Ames decided to add an agent to the rats' diet to neutralize the oxidants.
He tried lipoic acid, a mitochondrial antioxidant. The results were profound. Oxidants & oxidative damage to mitochondrial components dropped dramatically. Both the structure & function of the mitochondria improved. The rats' activity levels doubled...Both ingredients: Alcar & lipoic acid are marketed as dietary supplements. Consumers can even duplicate the dosages used in Juvenon's trials:
200 milligrams alpha-lipoic acid & 500 milligrams acetyl-L-carnitine, twice a day."
"Ames is convinced that simple B vitamin therapy could also combat some cases of migraines, mental retardation & many other maladies...
Genetic mutations result in deformed enzymes that don't work as well as normal ones.
Enzymes rely on molecular partners called coenzymes to do their job.
High amounts of B vitamins can boost levels of coenzymes, thereby improving binding function of defective enzymes."
"Ames & his colleagues have already devised a DNA test that can quickly assess oxidative damage to a person's genes. But those tests aren't cheap & multivitamins are."
"Ames" founded "a genomics & nutrition center."
"'If I'm going to get vitamins in the poor, I guess I'm going to have to do it myself,' he says."
http://discovermagazine.com/2002/oct/featradical Email Print
August 2011 archived at http://www.lef.org/magazine/mag2011/mag2011_all.htm
PQQ is added as a recommended supplement http://en.wikipedia.org/wiki/Pyrroloquinoline_quinone "Pyrrolo-quinoline quinone (PQQ) was discovered by J.G. Hauge as the 3rd redox cofactor after nicotinamide (tobacco nicotine) & flavin in bacteria (although they hypothesised that it was naphthoquinone). "
|Ashwaganda @ 67208-KSM-66-Ashwagandha-Telomerase-s.pdf (ksm66ashwagandhaa.com) Ashwagandha appears to increase/protect telomerase & thus protect/rejeuvinate/restore telomeres, the protective ends of chromosomes/DNA.|
"TA-65 + Astragalus extract + Cycloastragenol + Product B (appear to contribute to anti-aging).
TA-65 is a documented telomerase activator in animals. Its active ingredient is a naturally occurring polymer that activates the hTERT, which in turn activates the enzyme telomerase.
Telomerase...inhibits telomeres from shortening & TA-65 is said to increase overall telomere length. 75% of people who used this supplement reported improvement in skin & immune system function.
50% saw improvement in vision, libido & quality of sleep.
TA-65 is actually an extract of astragalus propinquus, available in a tablet as a telomere support supplement. Astragalus extract has been used in some parts of China for centuries as an herbal supplement.
It is now a known telomerase activator but only when used in very high concentrations.
While it is still a matter of debate, it is believed that the active ingredient in TA-65 is cycloastragenol, a compound extracted from astragalus.
Many people who advocate taking a cycloastragenol supplement recommend also adding a standardized astragalus extract to the regimen. The theory here is that there may be synergistic compounds at work in telomerase activation that are not present in cycloastragenol alone.
Isagenix Product B is somewhat different from the previous supplements.
It is marketed as a “super pill,” packed full of antioxidants designed to protect telomeres & other antioxidant enzyme activity for optimal health & defense against aging."
"Centella asiatica extract formulation (08AGTLF) can lead to significantly higher telomerase activation compared to untreated cells, as well as TA-65 & other supplements containing Astragalus extract & CAG.
This study...demonstrates that a natural formulation, such as Centella asiatica extract formulation (08AGTLF) can lead to such high telomerase activity relative to control cells."
|Berries @ https://truth11.com/2021/06/05/research-blueberries-increase-the-life-span-by-22-years-video/ (Organic) Blueberries, raspberries, blackberries, choke berries, eg. may increase longevity.|
Braverman, Dr Eric The Younger You #1
Braverman, Dr Eric The Younger You #2 http://www.bennyhinn.org/media/2008-10-30.asx
Braverman, Dr Eric The Path to a Younger You - 12/15/2008
Braverman, Dr Eric A Younger You Through Brain Health - 12/19/2008 - https://www.bennyhinn.org/media/2008-12-19.asx
|Combating Age-Related Brain Deterioration - 10/2011 - http://www.lef.org/|
|Curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tumour cells - PubMed (nih.gov) - Curcumin is a polyphenolic compound isolated from Curcuma longa (Turmeric) that appears to help reverse cancer by inhibiting telomerase in tumors.|
Denese, Dr. Adrienne - touts her facial skin
Glutathione (3 amino acids: cysteine, glycine,
glutamine) Glutathione - the Master Antioxidant -
Spring 2011 at http://www.amazingwellnessmag.com/
|Glutathione Patents - https://www.researchgate.net/profile/Herbert_Nagasawa -|
Goji fruit or juice can trigger the pituitary
gland to release the human (gh) growth hormone, somatotropin, helping to
restore youth. 6/2006
www.breakthroughs.com - Goji berry has 4 bioactive polysaccharides
(glyco-nutrients, a family of carbohydrates bound to proteins & produced by extreme stress.
Glyco-nutrition is science of saccharides/sugars that maintain cellular body communication.)
Kinetin - "Plant hormone
KINETIN delays the onset of many cellular & biochemical
characteristics associated with cellular ageing...Natural sources
of kinetin related cytokinins are:
Kurzweil - recommends supplements antioxidant
Coenzyme Q10, especially Phosphatidyl-choline
also - Biotechnology Will Stop Aging - (But this 'benefit" may eventually REMOVE true honest personal choice & informed consent, especially in areas concerning the good for the majority.)
|Matcha TEA @ https://www.aging-us.com/article/101483/text|
|NAC is recommended to increase/help boost body's gluthathione.|
NAD + 3/11/2015 @
"NMN isn't available as a consumer product. But Sinclair's report sparked excitement about NR, which was already on the market as a supplement called Niagen.
Niagen's maker, ChromaDex, a publicly traded Irvine, Calif., company, sells it to various retailers, which market it under their own brand names...
Elysium Health, jumped into the NAD game by unveiling another supplement with NR. Dubbed Basis, it's only offered online by the company." See: https://www.elysiumhealth.com/en-us/knowledge/science-101/everything-you-need-to-know-about-nicotinamide-adenine-dinucleotide-nad
1. Calorie restriction - Restricting calories (20-30% less than what you normally consume)
+ fasting have been shown to increase NAD+ levels & increase activation of SIRT1.
This SIRT1 activation, scientists say, is why calorie restriction has been associated with increased life span in animal studies.
2. Nicotin-amide riboside is a newly discovered form of vitamin B3, which is found in trace amounts in milk. No one really thought much about it until scientists discovered that our bodies convert it into NAD+. 2 recent human trials on NR-containing supplements found that they both effectively increased levels of NAD+ in the body.
3.Wearing sunscreen or protective clothing can help minimize that damage & preserve NAD+.
A healthy, whole-food-based diet & a regular exercise routine (especially HIIT-type workouts)
can't hurt, either, as they both boost the health of your mitochondria and may help your body use NAD+.
4.NR-treated mice had less DNA damage, higher neuroplasticity, increased production of new neurons & lower levels of neuronal damage. In the hippocampus area of the brain (where damage & loss of volume is found in people with dementia), NR seemed to clear existing DNA damage or prevent it from spreading farther.
The NR-treated mice also performed better on memory tests.
5.Increasing our levels of NAD+ may help boost metabolism & prevent weight gain...
Positive results...were due to increased activation of the sirtuins SIRT1 & SIRT3, which led to improved oxidative metabolism. None of the mice receiving NR showed signs of diabetes.
6.Supplementation with NAD+ precursors led to DNA repair and an improvement in the health of muscle tissue within the 1st week, to the point where researchers couldn't tell the difference between the tissue of a mouse that was 2 years old and a mouse that was 4 months old. 9/26/2018
https://www.webmd.com/vitamins/ai/ingredientmono-1016/nadh - Other
B-DPNH, BNADH, Co-enzyme 1, Enada, NAD, Nicotin-amide Adénine Di-nucléotide, Nicotin-amide Adenine Di-nucleotide Hydrate, Reduced DPN, Reduced Nicotin-amide Adenine Di-nucleotide...NADH seems safe for most people when used appropriately & short-term, up to 12 weeks (3 months/90 pills). Most people do not experience any side effects when taking the recommended amount each day, which is 10 mg.
|Oxygen @ Israeli scientist claims to 'reverse' aging in blood cells | The Times of Israel 11/22/2020 or 11/18/2020 Aging | Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells : a prospective trial - Full Text (aging-us.com)|
|PQQ - http://pyrroloquinoline-quinone.com/pqq-info/pqq-rich-food/ - Related food sources: natto (fermented beans - estrogenic - for women), & (RAW:) papaya, celery, parsley, spinach, kiwi.|
Ribose and cysteine - Nagasawa,
H. T. created a method to Enhance Delivery of Glutathione & TP Levels
in Cells by using ribose & cysteine. -
Advocate is - Colbert, Dr Don & Mary - Medical Breakthroughs for Healthy Living #2 http://www.bennyhinn.org/media/2011-3-1.asx - 3/1/2011
L-cysteine [2(RS)-D-ribo-(1′, 2′, 3′, 4′-Tetrahydroxybutyl)thiazolidine-4(R)-carboxylic acid (Ribose-Cysteine, RibCys)] -
RiboCeine™ is the amino acid cysteine fused with the sugar ribose...
Cysteine itself is neurotoxic when administered to mammals & is rapidly degraded.
Dr. Nagsawa spent years of research testing various compounds to find 1 which safely & effectively delivered the fragile cysteine molecule inside the cell, with the bonus effect of providing ribose for ATP production.
Liver cell tests show RibCeine™ is 300% more effective in raising glutathione levels than N-Acytl-Cysteine, which is used in MaxGXL Demand Release. We’ve all heard of time release vitamins (with toxic binders)...
MaxONE takes it to the next level with on-demand release.
The RiboCeine is absorbed into the cells where it waits. When the body needs to make more glutathione & seperates it into the cysteine & ribose which are then used for glutathione & ATP production."
L-glutathione - www.designsforhealth.com
Ribose + cysteine - Championed by Dr. Gordon
Crozier in book Healing One Cell at a
Time. Chapter 3 says that best current
method to help cells & bypass GI system deterioration is to combine
D-Ribose with L-Cysteine to help body produce its own gluththione. "If
you don't have your glutathione levels corected, you won't begin to have
proper methylation, a process by which a hydrogen ion is removed from the
ell & replaced with a methyl gorou...to utilize certain vitamins, for
detoxification & for all the biochemical pathways to operate correctly...
Toxins cause genetic glithes & block up the pathways. Gluthione unblocks those pathways."
Chapter 11 recommends glutathione (via precursors D-Ribose + L-Cysteine), grape seed, reverstrol, carotenoids, vitamins E & C, alpha lipoic acid, CoQ10 & xanthophylls).
acid], RibCys (D-Ribose-L-cysteine)
&, to a lesser extent, CySSG (L-cysteine-glutathione
mixed sulfide) provided protection against colitis in this murine
model, which further supports a possible therapeutic application of
GSH-repleting agents in IBD patients.
Raw Coconut Kefir Margarita Demo - Part 1 - Longevity Now Experience
with David Wolfe
|https://alsearsmd.com/about/ 1 specialty is anti-aging.|
- Gently exercise ALL body muscles daily.
|Villeponteau, Bryant @ https://www.lifecoderx.com/bryant-villeponteau-phd-formulator-of-stem-cell-100/ + Transcript of Interview With Dr. Bryant Villeponteau + his supplement @ Stem Cell 100 -|
|FOXO gene - http://video.pbs.org/video/1754557053/ - Can We Slow Aging?|
National Geographic Explorer Dan Buettner
http://en.wikipedia.org/wiki/Dan_Buettner has traveled the globe
to uncover the best strategies for longevity found in the world's
http://www.bluezones.com/ + http://abcnews.go.com/Technology/LivingLonger/Story?id=2805247&page=1 +
Science at your fingertips -
such as How Does The Brain Work? (#503)
the role of the 7 mammalian
sirtuins, SIRT1 to SIRT7
Have Israeli scientists discovered the fountain of youth? -
"Sirtuins are highly conserved deacetylases that have been shown to regulate lifespan in yeast, nematodes & fruitflies1." (with helpful implication in male species).
Electro Magnetic Frequencies